Statins & Weight Loss. Statins help reduce the risk of coronary heart disease. Poor lifestyle and eating choices have dramatically increased the prevalence of obesity, diabetes and high blood pressure among Americans, and statins have become a key tool in the fight against heart disease. They are indicated for the treatment of several conditions, including high cholesterol, high triglycerides and arteriosclerotic vascular disease. They are also used for the prevention of heart attack and stroke. The most frequent complaints are headaches, abdominal pain, muscle pain, diarrhea, nausea and vomiting. Statins and Weight Loss. Reducing body weight and increasing exercise are first-line treatments for lowering the risk of cardiovascular disease. Physicians recommend all patients participate in regular physical activity and eat a low-fat diet to prevent the need for statin use. Weight loss is the primary goal of these lifestyle interventions and guidance from specialized, structured support programs may help with long-term success and adherence.
Home > Prescription Drugs > Simvastatin > Simvastatin and Weight Gain. Simvastatin and Weight Gain. There are contrasting views as to whether simvastatin can indeed cause weight gain or not. Beatrice Golomb of the University of California-San Diego School of Medicine, it suggested that simvastatin can cause significant sleep problems which can subsequently lead to weight gain and aggression. The researchers further stressed that the disruption in sleep pattern can affect the patient’s quality of life and have negative effects on health that includes weight gain and insulin resistance. Although weight gain is rarely reported by patients taking simvastatin, if it does occur you may need to seek medical attention. If you notice weight gain while on simvastatin therapy, there are several things that you can do to manage your weight. If the weight gain continues despite a change in your lifestyle, you should talk to your physician.
Common Questions and Answers about Simvastatin side effects weight loss. Take the simvastatin , but watch the side effects over the next months. Unless you have experienced the full brunt of side effects from statins, you can not state "just stick it out". The side effects are unbearable. Dear Stefano, I will start the IFN add-on this Saturday and is there any advice to tackle with the side effects (I read that some experienced dehydration and so I will keep myself hydrated at all times)? The main study for Simvastatin was the 4 S trial which proved that the incidence rate for side effects at 40 mg of Simvastatin was 1 in 2,220 prescriptions. All these meds have scary side effects and say no drinking alcohol but the HCG drops have 20%.alcohol. I learned that, even though they are highly effective, they could have serious side effects for some people with certain existing ailments, and that stopoing their usage could make the virus have a really fierce come-back. If you're treating me with statins, and I know you've told me that there could be side effects , what are the side effects that you'd want me to get in touch with you right away on and others that could wait? So much so that the FDA is considering removing liver damage from the list of side effects . I didn't see the Dr to ask him about it because he was on vacation, but I also didn't think to ask him of any possible side effects .
Does Simvastatin Cause Weight Gain? 26 y/o Male currently on (simvastatin) and (aciphex) . I am in the Navy and my doctor put me on simvastatin about 2 months ago. Last year I wasnt in such great shape but came back and dropped 35 lbs. Show more 26 y/o Male currently on (simvastatin) and (aciphex) . But since I have been taking it i have gained almost 20lbs back and put 3 inches on my waist. I know it wouldnt be that bad but I have also in the last 2 months been not as apt to run and exercise as I used to. I have not changed my diet and nothing else is different except stress. So my question is, does Simvastatin cause weight gain in some people? I have heard yes from some people and no from others.
Newer beta blockers, such as carvedilol (Coreg), don't usually cause weight gain as a side effect. However, the beta blockers that can cause weight gain usually aren't prescribed unless other medications haven't worked, or if you have a specific heart condition that requires taking those medications. Also, if you switch from taking a water pill (diuretic) to a beta blocker as a treatment for high blood pressure, you may gain a few pounds of weight that the diuretic kept off. If you're taking a beta blocker for heart failure, tell your doctor immediately if you begin to gain more than 3 to 4 pounds (about 1.5 to 2 kilograms), particularly if the weight gain continues beyond your first week of taking the drug.
Drugs Home > Simvastatin and Weight Gain. Simvastatin and Weight Gain. If you experience unexpected weight gain while taking simvastatin, however, you should talk to your healthcare provider. Does Simvastatin Cause Weight Gain? While weight gain is a rarely reported side effect with some other cholesterol medications , it is not a recognized side effect at all with simvastatin ( Zocor ®). Weight Gain With Simvastatin: Suggestions. If you are noticing unexplained weight gain with simvastatin, there are some things that you can do. If the weight gain continues, talk to your healthcare provider.
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Will my statin drug cause weight gain as a side effect? Statins increase weight and blood sugar levels and raise the risk of basic mechanism can lead to weight gain and a modest increase in diabetes risk. I can honestly say I do not believe statins and weight gain are. IT WAS THE CHOLESTEROL MEDICATION THAT CAUSED WEIGHT GAIN. Statins can cause liver damage and muscle problems; although not common,. Research shows sleep problems can promote weight gain. Very rarely, statins can cause life-threatening muscle damage called . Zocor (simvastatin) is a statin that lowers lipids and cholesterol levels used in effects of Zocor including confusion, fever, painful urination, weight gain,. Q: Can Zocor cause weight gain? Like all medications, statins can cause side effects. Study Shows Weight Gain, More Calories Consumed a potential hazard with statins, where the focus on "cholesterol levels can be distracting . Can statins cause weight gain. With a Web MD Account you can: Track your way to weight loss success; Manage your family's vaccinations; Join the conversation. Statins Can Damage Your Health. APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer's by Stephanie Seneff.
Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Pains in the stomach, side, or abdomen, possibly radiating to the back. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Burning feeling in the chest or stomach. Pain or tenderness around the eyes and cheekbones. Tenderness in the stomach area. Other side effects not listed may also occur in some patients. You may report side effects to the FDA at 1-800-FDA-1088.
Simvastatin and Weight Gain. One of the most rarely discussed of all possible simvastatin side effects is weight gain, mostly because it’s not a life threatening condition, like muscle pain or other dangerous side effects. To start with, there are many reports from patients who claim that they gained pounds while taking simvastatin, and some lost them after discontinuing the medication. Did you eliminate products that cause weight gain from your diet? Does simvastatin cause weight gain? Officially, weight gain is not recognized or listed as a side effect of simvastatin. So, claiming that dramatic weight gain in patients taking simvastatin has nothing to do with the medication is at least unwise. Simvastatin may not be the direct cause of weight gain. However, putting on pounds rapidly means that something in you body works not the way it should and simvastatin make it more obvious.
First, taking pills such as atorvastatin , (Lipitor and generic), lovastatin (Altoprev, Mevacor, and generic), or simvastatin (Zocor and generic) may make you think you can eat as much as you like, new research suggests. Second, statins can cause muscle pain and weakness, which may make you less likely to exercise. While the eating habits of people who didn’t take statins stayed pretty much the same, those who did take the cholesterol-lowering drugs gradually consumed more and more over time, according to a 10-year dietary study of nearly 28,000 U. Statins appear to “provide a false reassurance” and a belief that the drugs can “compensate for poor dietary choices,” wrote Rita F. Statins might also contribute to weight gain by causing muscle pain and weakness, which in turn can make you less physically active. Other published materials suggest the number is closer to between 5 and 10 percent of people. High-dose statins have been targeted by the FDA, which found that the 80-mg dose of simvastatin (Zocor and generic as well as the combination drug Vytorin and Simcor) was far more likely to cause muscle injury than the lower doses or other drugs in the same class, especially in the first year of taking them—and that it was particularly a problem for women , in addition to those also taking certain blood pressure drugs . Based on those findings, the FDA recommended that people who start taking simvastatin , or who have been taking it for less than a year, start with a lower dose. Our consultants take that advice one step further and recommend that most people who start taking any statin medication begin with the lowest available dose, increasing slowly only if necessary. Muscle pain associated with statins is most often not serious and typically can be resolved by switching to a lower dose, or different statin drug. If you’re taking a statin and notice muscle pain, tenderness or weakness, dark or brown-colored urine, or unexplained tiredness, it’s important to call your doctor right away as that could be a sign of a fortunately rare, but deadly, side effect.
Hi Anthony, you're very knowledgeable about cholesterol, statin drugs and weight training, so I figure you're the best person to clear something up for me. The researchers observed that higher self-reported dietary cholesterol intake and serum cholesterol levels were associated with greater lean mass gains. Given that statins lower blood cholesterol, and have been documented to lower testosterone in some users, they would thus be expected to be associated with poorer muscle growth in weight training individuals. But surprisingly, in the same study that higher cholesterol levels to be associated with greater muscle growth, statin use was also associated with greater hypertrophy. Given that higher cholesterol levels are associated with better health and longevity in older folks, this may then give the erroneous impression that statins are "healthy" in observational studies, when it is in fact the users themselves that have better underlying health. What I will say is this: if optimal health, performance and longevity are important to you, statins would have to be about the worst possible addition to your hypertrophy regimen. Can You Gain Muscle and Lose Fat at the Same Time? Anthony, what's your opinion on gaining muscle and losing fat at the same time? The best strategy at that point is to focus on distinct fat loss and muscle gain phases. You may want to give The Great Cholesterol Con to your cardiologist and tell him to read Chapter 4 also. Cholesterol metabolism and body composition in women: the effects of moderate weight loss.
Statins and weight gain;. * Can statins cause weight gain May 15, 2014 . Will my statin drug cause weight gain as a side effect? Statins can cause side effects. Loss of appetite or weight gain ; difficulty sleeping. Can statins cause weight gain. Statins increase weight and blood sugar levels and raise the risk of basic mechanism can lead to weight gain and a modest increase in diabetes risk. Statins can cause liver damage and muscle problems; although not common,. Research shows sleep problems can promote weight gain. Very rarely, statins can cause life-threatening muscle damage called . Q: Can Zocor cause weight gain? Like all medications, statins can cause side effects. Study Shows Weight Gain, More Calories Consumed a potential hazard with statins, where the focus on "cholesterol levels can be distracting . Sign up for weight loss support emails; statins and weight gain;.
Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased. Grapefruit can increase the amount of this medication in your bloodstream. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Talk to your doctor about the benefits and risks. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Do statins cause hair loss? Hair loss, or alopecia, is a very rare side effect of all statin drugs. About 1 percent of people taking statins report hair loss. We don't know exactly why statins might cause hair loss. But we do know that cholesterol is an important building block for steroid hormones, which play a role in hair growth. But if statins really caused hair loss, I think we'd hear more reports of it, given the millions of statin takers. If no other cause can be found for your hair loss, you could ask your clinician about stopping the statin for a few months.
Among the side effects with Zocor are: A: The recommended Zocor (simvastatin) dosing depends on the indication for treatment and age of the patient. Q: What are the side effects of Zocor? More serious side effects of Zocor are possible and include problems with muscle and the liver. The warnings and precautions associated with Zocor are also possible with the generic equivalent of Zocor. This is not a complete list of the side effects associated with Zocor (simvastatin). The most common side effects with Zocor are: upper respiratory infection, headache, abdominal pain, constipation, and nausea. Zocor is used for the treatment of high cholesterol and other uses. A: Muscle aches and pain can be side effects of many of the statin medications, including Zocor (simvastatin). Zocor decreases bad cholesterol and total cholesterol levels in the blood.
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Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Tell your doctor and pharmacist if you are allergic to simvastatin, any other medications, or any of the ingredients in simvastatin tablets. Your doctor will probably tell you not to take simvastatin if you are taking these medications. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Other medications may also interact with simvastatin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor will probably tell you not to take simvastatin if you have liver disease or if the tests show that you may be developing liver disease. Tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking simvastatin, stop taking simvastatin and call your doctor immediately. Tell your doctor if you are breastfeeding. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking simvastatin. Ask your doctor about the safe use of alcoholic beverages while you are taking simvastatin. Call your doctor if you have any unusual problems while you are taking this medication. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking simvastatin.
Zocor in Detail with Side Effects. Zocor (simvastatin) is a statin that lowers lipids and cholesterol levels used in conjunction with lifestyle changes such as a low-fat, low cholesterol diet, and exercise to reduce the chances of cardiovascular disease and ischemic strokes in patients with elevated lipids and cholesterol. Contact your doctor if you have severe side effects of Zocor including confusion, fever, painful urination, weight gain, muscle pain, weakness, increased hunger or thirst, or jaundice (yellowing of the skin or eyes). Patients should stop using Zocor and contact their prescribing doctor at once if they have any of these serious side effects of allergic reactions (shortness of breath, rash, swelling), atrial fibrillation, muscle pain, tenderness, or weakness with fever or flu symptoms, and dark colored urine. Zocor should not be used in pregnant women and has not been studied in lactating women; its use in the pediatric population is limited to those patients described above. In the pre-marketing controlled clinical studies and their open extensions (2,423 patients with median duration of follow-up of approximately 18 months), 1.4% of patients were discontinued due to adverse reactions. The most commonly reported adverse reactions (incidence ≥ 5%) in simvastatin controlled clinical trials were: upper respiratory infections (9.0%), headache (7.4%), abdominal pain (7.3%), constipation (6.6%), and nausea (5.4%). In 4 S involving 4,444 (age range 35-71 years, 19% women, 100% Caucasians) treated with 20-40 mg/day of ZOCOR (n=2,221) or placebo (n=2,223) over a median of 5.4 years, adverse reactions reported in ≥ 2% of patients and at a rate greater than placebo are shown in Table 2. Table 2: Adverse Reactions Reported Regardless of Causality by ≥ 2% of Patients Treated with ZOCOR and Greater than Placebo in 4 S. In the Heart Protection Study ( HPS ), involving 20,536 patients (age range 40-80 years, 25% women, 97% Caucasians, 3% other races) treated with ZOCOR 40 mg/day (n=10,269) or placebo (n=10,267) over a mean of 5 years, only serious adverse reactions and discontinuations due to any adverse reactions were recorded. Discontinuation rates due to adverse reactions were 4.8% in patients treated with ZOCOR compared with 5.1% in patients treated with placebo. The incidence of myopathy / rhabdomyolysis was < 0.1% in patients treated with ZOCOR. In a clinical trial in which 12,064 patients with a history of myocardial infarction were treated with ZOCOR (mean follow-up 6.7 years), the incidence of myopathy (defined as unexplained muscle weakness or pain with a serum creatine kinase [CK] > 10 times upper limit of normal [ULN]) in patients on 80 mg/day was approximately 0.9% compared with 0.02% for patients on 20 mg/day. The incidence of rhabdomyolysis (defined as myopathy with a CK > 40 times ULN) in patients on 80 mg/day was approximately 0.4% compared with 0% for patients on 20 mg/day. In a 48-week, controlled study in adolescent boys and girls who were at least 1 year post- menarche , 10-17 years of age (43.4% female, 97.7% Caucasians, 1.7% Hispanics, 0.6% Multiracial) with heterozygous familial hypercholesterolemia (n=175), treated with placebo or ZOCOR (10-40 mg daily), the most common adverse reactions observed in both groups were upper respiratory infection, headache, abdominal pain, and nausea [see Use in Specific Populations and Clinical Studies ].
Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysis. In most cases, these elevations were mild, transient, and not associated with clinical symptoms.[ Ref ] In other patients, elevations in liver function tests were transient and returned to normal with continued simvastatin therapy. Simvastatin should be discontinued in patients with persistent, significant elevations (3 times normal) in liver function parameters.[ Ref ] Frequency not reported: A case of lupus-like syndrome which has been reported with other HMG-Co A reductase inhibitors, positive ANA, ESR increase, polymyalgia rheumatica, and vasculitis[ Ref ] Weise WJ, Possidente CJ "Fatal rhabdomyolysis associated with simvastatin in a renal transplant patient." Am J Med 108 (2000): 351-2. Pedersen TR, Berg K, Cook TJ, Faergeman O, Haghfelt T, Kjekshus J, Miettinen T, Musliner TA, Olsson AG, Pyorala K, Thorgeirsso "Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study." Arch Intern Med 156 (1996): 2085-92. Walker JF "Simvastatin: the clinical profile." Am J Med 87 (1989): s44-6. Finsterer J, Zuntner G "Rhabdomyolysis from Simvastatin triggered by infection and muscle exertion." South Med J 98 (2005): 827-9. Vanpuijenbroek EP, Dubufvereijken PWG, Spooren PFMJ, Vandoormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil." J Intern Med 240 (1996): 403-4. Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem." Nephron 89 (2001): 117-8. Van Puijenbroek EP, Du Buf-Vereijken PW, Spooren PF, van Doormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil." J Intern Med 240 (1996): 403-4. It is possible that some side effects of simvastatin may not have been reported.
Simvastatin and Weight Loss. Many patients wonder about the connection between simvastatin and weight loss and ask if simvastatin can help lose pounds. Does simvastatin cause weight loss? As of 2010, there are no clinical trials that prove or deny the connection between simvastatin and weight loss or weight gain . Why is simvastatin is associated with weight loss? Healthy lifestyle inevitably brings about weight loss and other positive changes in overweight patients taking simvastatin. That’s why simvastatin is frequently associated with weight loss. Simvastatin and Weight Loss Surgery. Can I have a weight loss surgery if I’m taking simvastatin?
What is simvastatin (Zocor)? Simvastatin is used to lower cholesterol and triglycerides (types of fat) in the blood. Simvastatin is also used to lower the risk of stroke , heart attack , and other heart complications in people with diabetes , coronary heart disease , or other risk factors. Simvastatin is used in adults and children who are at least 10 years old. Simvastatin may also be used for purposes not listed in this medication guide. What are the possible side effects of simvastatin (Zocor)? Stop using simvastatin and call your doctor at once if you have: This is not a complete list of side effects and others may occur. What is the most important information I should know about simvastatin (Zocor)? Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Many other drugs can interact with simvastatin. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects.
Simcor in Detail with Side Effects. Simcor ( niacin extended-release/ simvastatin ) is a combination of a B vitamin ( vitamin B 3 ) and a cholesterol -lowering medication used to lower cholesterol and triglycerides (types of fat) in the blood. Common side effects of Simcor include flushing (warmth, redness, itching, or tingling of the skin, especially of the face/neck), sweating, dizziness, or chills within 2 to 4 hours after taking this medication. Our Simcor (niacin extended-release/simvastatin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Simcor in Detail - Patient Information: Side Effects. Stop taking niacin and simvastatin and call your doctor at once if you have any of these serious side effects: Flushing episodes (i.e., warmth, redness, itching and/or tingling) were the most common treatment-emergent adverse reactions, occurring in up to 59% of patients treated with SIMCOR. More Common Adverse Reactions: In addition to flushing, adverse reactions occurring in ≥ 3% of patients (irrespective of investigator causality) treated with SIMCOR are shown in Table 4 below: There were 5 cases of rhabdomyolysis reported, 4 (0.2%) in the simvastatin plus NIASPAN group and one ( < 0.1%) in the simvastatin plus placebo group [see WARNINGS AND PRECAUTIONS ]. In pre-marketing controlled clinical studies and their open extensions (2,423 patients with mean duration of follow-up of approximately 18 months) 1.4% of patients discontinued due to adverse reactions. The most commonly reported adverse reactions (incidence > 1%) in simvastatin controlled clinical trials were: headache (3.5%), abdominal pain (3.5%), constipation (2.3%), upper respiratory infection (2.1%), diarrhea (1.9%), and flatulence (1.9%). In placebo-controlled clinical trials (n=245), flushing episodes were the most common treatment-emergent adverse events (up to 88% of patients) for niacin extended-release. See also the full prescribing information for niacin extended release (Niaspan) and simvastatin products. The following additional adverse reactions have been identified during postapproval use of simvastatin.
Beth Greenwood is an RN and has been a writer since 2010. Like all medications, statins have side effects and may affect your weight. Statins can cause liver damage and muscle problems; although not common, these are the most dangerous side effects. The most common side effects from statins are muscle and joint aches, but other side effects include nausea, diarrhea and constipation. Two less well known side effects are problems with cognition – thinking – and problems with sleep. Statins and Sleep. Beatrice Golomb, the lead researcher on “The Statin Study,” patients on simvastatin are more likely to have sleep disruption and poor sleep quality. It is this side effect, which may be related, first, to a tendency to gain weight while on simvastatin, and second, to a tendency to lose the weight when the drug is discontinued.
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Stop taking this medication and tell your doctor right away if you become pregnant. You should not take this medicine if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease. The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. These drugs should not be used while you are taking this medicine: Do not take simvastatin if you are pregnant. Do not breast-feed while you are taking this medicine. If you take simvastatin more than once daily, take it with meals. While using simvastatin, you may need frequent blood tests at your doctor's office. You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. Do not stop taking this medicine unless your doctor tells you to. Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.