How does pancreatic cancer cause weight loss


Symptoms of Pancreatic Cancer

Symptoms of Pancreatic Cancer. Patients may experience different symptoms depending on the location, type and stage of the cancer. A person with advanced pancreatic cancer may also experience ascites (fluid in the abdomen) and blood clots. Follow the links below for more information about each symptom commonly associated with pancreatic cancer. If someone experiences one or more of the symptoms mentioned in this section, it does not mean that he or she has pancreatic cancer. Learn About Pancreatic Cancer. Information provided by the Pancreatic Cancer Action Network, Inc. Information also may be provided in aggregate or limited formats to third parties to guide future pancreatic cancer research and treatment efforts. Facing Pancreatic Cancer. more...



Signs of Pancreatic Cancer

she finally couldnt take it and went to the dr. She was misdiagnosed over and over until she was finally diagnosed with pancreatic cancer.  My mother was diagnosed in July of 2004 with pancreatic cancer and she died on October 30th of that same year. By the time they diagnosed him with pancreatic cancer and secondary liver cancer, he had gone unconsious. Finally She had an ultrasound and then a CT that showed a 3cm mass located on the neck of her pancreas. An ERCP/EUS showed that the cancer had invaded the mesentriac artery, portal vein, and aorta so it was not resectable. From that point on she was in and out of the hospital. For the first week, she was tired but able to go around to the different hospitals and meet with the doctors, etc. She was told on 9th May that is was pancreatic cancer and she died 9 days later on the 18th. They removed the tail of my pancreas and spleen (it was affected). She underwent an abdominal CAT scan and there it was, a huge tumor in the body of her pancreas. more...



Pancreatic cancer - Wikipedia, the free

The most common, pancreatic adenocarcinoma, accounts for about 85% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. One to two in every hundred cases of pancreatic cancer are neuroendocrine tumors , which arise from the hormone-producing cells of the pancreas. There are usually no symptoms in the disease's early stages, and symptoms that are specific enough to suspect pancreatic cancer typically do not develop until the disease has reached an advanced stage. Pancreatic cancer rarely occurs before the age of 40, and more than half of cases of pancreatic adenocarcinoma occur in those over 70. [4] Pancreatic cancer is the fifth most common cause of death from cancer in the United Kingdom, [12] and the fourth most common in the United States. Cystadenocarcinomas account for 1% of pancreatic cancers, and they have a better prognosis than the other exocrine types. The spread of pancreatic cancer to other organs ( metastasis ) may also cause symptoms. [2] The genetic alterations in several other types of pancreatic cancer and precancerous lesions have also been researched. However, the combination of gemcitabine with erlotinib was found to increase survival modestly, and erlotinib was licensed by the FDA for use in pancreatic cancer in 2005. [2] [66] Overall five-year survival for pancreatic cancer in the US has improved from 2% in cases diagnosed in 1975–77, and 4% in 1987–89 diagnoses, to 6% in 2003–09. [91] In 2014, an estimated 46,000 people in the US are expected to be diagnosed with pancreatic cancer and 40,000 to die of it. Globally pancreatic cancer is the 11th most common cancer in women and the 12th most common in men. Pancreatic cancer is the 10th most common cancer in the UK (around 8,800 people were diagnosed with the disease in 2011), and it is the 5th most common cause of cancer death (around 8,700 people died in 2012). more...



Pancreatic Cancer : Diagnosis and Management

Pancreatic Cancer: Diagnosis and Management. The link between risk of pancreatic cancer and other factors (e.g., diabetes, obesity) is less clear. The American Cancer Society estimated that 31,860 Americans would be diagnosed with pancreatic cancer in 2004, and that 31,270 would die from the disease. Pancreatic cancer rarely occurs in persons younger than 50 years, and the risk increases with age. Cancer of the pancreas and biliary tract. Accuracy of Imaging Studies for the Diagnosis of Pancreatic Cancer. Surgical resection is the only potentially curative treatment for patients with pancreatic cancer, although many patients are not candidates for resection. A prospective study of cigarette smoking and the risk of pancreatic cancer. Physical activity, obesity, height, and the risk of pancreatic cancer. Association between nonsteroidal antiinflammatory drug use and the incidence of pancreatic cancer. Hereditary pancreatitis and the risk of pancreatic cancer. Clinical presentation and ultrasonography in the diagnosis of pancreatic cancer. more...



Weight Loss Precedes Cancer Specific Symptoms in

2 Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, MN. 5 Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic Rochester, MN. Chari, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, Email: [email protected] , Phone: (507) 266-4347, Fax: (507) 284-5486. We compared body weight (kg) and FBG (mg/dl) at DM onset, 1–2 years prior and at index date in the two groups. Prior to onset of DM, Pa CDM and type 2 DM had similar body weight (P=.80). However, at onset of DM 59% of Pa CDM lost weight vs. At onset of DM, 56% of type 2 DM gained weight vs. By index date, Pa CDM lost more weight than type 2 DM (8.3±8.3 vs. more...



Weight Loss

Weight loss is common among people with cancer and is often the first noticeable sign of the disease. As many as 40% of people with cancer report unexplained weight loss at the time of diagnosis, and up to 80% of people with advanced cancer experience weight loss and cachexia, or wasting, which is the combination of weight loss and muscle mass loss. Weight loss and muscle wasting also often come with fatigue , weakness, loss of energy, and an inability to perform everyday tasks. Controlling cancer-related weight loss is important for your comfort and well-being. Consider asking your doctor about receiving food through a tube that goes directly to the stomach, which may help people with head and neck or esophageal cancers who are having difficulty chewing or difficulty swallowing . Megestrol acetate (Megace) is a progesterone hormone that can improve appetite, weight gain, and a person's sense of well-being. Steroid medications can increase appetite, improve a person's sense of well-being, and help with nausea, weakness, or pain. Other medications are being studied to help people with cancer improve their appetite and gain weight. Nutrition counseling may help people with cancer get essential nutrients, such as protein, vitamins, and minerals into their diet and maintain a healthy body weight. You can also find a dietitian through the Academy of Nutrition and Dietetics. These details can help you work with your health care team to find the best way to maintain your weight, or gain needed weight, during cancer treatment. more...



Pancreatic Cancer : Types, Symptoms, Signs

Body - The middle portion of the pancreas. Tail - The leftmost portion of the pancreas that lies adjacent to the spleen. The most common type of pancreatic cancer arises from the exocrine glands and is called adenocarcinoma of the pancreas. The endocrine glands of the pancreas can give rise to a completely different type of cancer , referred to as pancreatic neuroendocrine carcinoma or islet cell tumor . By the time that pancreatic cancer is diagnosed, many people already have disease that has spread to distant sites in the body (about 53%). Pancreatic cancer is also relatively resistant to medical treatment, and the only potentially curative treatment is surgery. In 2010, approximately 43,000 people in the United States were diagnosed with pancreatic cancer, and approximately 36,000 people died of this disease. These numbers reflect the challenge in treating pancreatic cancer and the relative lack of curative options. more...



Cancer, Weight Changes, Muscle Loss, Fatigue

Treating and managing these symptoms can help you feel better and allow you to continue with more of your usual activities. These substances can lead to weight loss, muscle loss, and a decrease in appetite. They can also lead to side effects such as nausea, vomiting, and mouth sores, which can affect your ability to eat normally, further contributing to weight and muscle loss. Fatigue is also a factor, since the decreases in exercise and other physical activities that happen when you’re not feeling well can also contribute to muscle loss. How are weight changes and muscle loss treated? These drugs can increase appetite for some people and may help to prevent weight and muscle loss, but they do not build up lost muscle tissue. What can I do to help maintain my weight and build strength? You can also try some upper body exercises while sitting in a chair – moving your arms up and down and front to back can help maintain flexibility. Making a fist and lifting your arms up and down in front of you can increase strength. Note the type of exercises or other physical activities you do and how they affect your mood and energy level. Nutritionists and physical or occupational therapists can advise you on other ways to maintain your weight and build strength as you cope with cancer. more...



Colon Cancer and Unexplained Weight Loss

Many of us wouldn't want to question unexplained weight loss. We'd just be happy to be losing weight! Though the prospect of losing weight without even trying may seem like a blessing, it really is something to question. Reasons for Unintentional Weight Loss. Possible causes of unintentional weight loss include depression, frequent diarrhea, hyperthyroidism (an overactive thyroid gland), infection, poor nutrition, AIDS, and cancer. If you're trying to figure out why someone else is losing weight unintentionally, you may also want to look into drug abuse, eating disorders, and smoking. Unexplained Weight Loss and Colon Cancer. You're unlikely to notice the diversion of blood and nutrients, but sometimes tumors release chemicals that increase the body's metabolism (such as burn calories faster), which can lead to unexplained weight loss. Medical Attention for Unexplained Weight Loss. (That would be about 10 pounds for a 200-pound person.) You should also call your doctor if you experience unexplained weight loss in conjunction with other potential colon cancer symptoms . "Colon Cancer: Signs and Symptoms." Mayo Clinic 17 Aug. "Signs and Symptoms of Cancer." American Cancer Society 28 Feb. "Weight Loss - Unintentional." National Institutes of Health 22 Jan. If you're trying to figure out why someone else is losing weight unintentionally, you may also want to look into drug abuse, eating disorders , and smoking. more...



Appetite Loss

Changes in appetite are common with cancer and cancer treatment. Ongoing appetite loss may lead to weight loss , not getting the nutrients from food that the body needs, and loss of muscle mass and strength, all of which are serious complications. The combination of weight loss and muscle mass loss is called cachexia, or wasting. Appetite loss in a person with cancer has many causes: Some types of cancer–including ovarian, pancreatic, and stomach cancers–may cause a loss of appetite, usually by affecting a person's metabolism, which is the process of the body breaking down food and turning it into energy. Treatment for conditions such as mouth sores, dry mouth, pain, or depression may help improve appetite. Treatments for appetite loss and associated weight loss may include medications that increase appetite and medications that help move food through the intestine. Megestrol acetate (Megace) or medroxyprogesterone are forms of the progesterone hormone that can improve appetite and weight gain. Steroid medications can increase appetite, improve a person's sense of well-being, and help with nausea, weakness, or pain. Other medications are being studied to help people with cancer improve their appetite and gain weight. Medications that help food move through the intestine, nutritional supplement drinks, and tube feeding, which is the use of a tube that passes through the nose into the stomach, can also be helpful. Although you may not feel like eating, remember that getting good nutrition and keeping a healthy weight are important parts of your recovery. Eating well can also help you better cope physically and emotionally with the effects of cancer and cancer treatment. If the smell or taste of food makes your nauseous, eat food that is cold or at room temperature to decrease its odor and reduce its taste. Ask your doctor about ways to relieve gastrointestinal symptoms, such as nausea, vomiting, and constipation or if you are having any difficulty with managing pain. more...



Symptoms and Side - Effects - Johns Hopkins Pathology

Also, tumors of the pancreas often interfere with digestion which furthur contributes to weight loss. The anti-cancer drugs given during chemotherapy affect normal cells as well as cancer cells. When normal blood cells are affected, the blood cells may not clot well which may cause the patient to bleed easily. Infection caused by obstruction of the bile ducts and/or biological therapy (vaccines). Removal of part of the pancreas with the cancer may cure the diabetes. Surgery, radiation therapy, and/or chemotherapy are all a strain on the body and often cause fatigue. Obstruction of bile ducts can lead to infection in the bile ducts and possibly the liver. The last portion of the bile duct joins with the pancreatic duct in the back of the head of the pancreas and empties into the duodenum. This leads to a visible yellowing of the eyes and the skin. The cells of the digestive tract also divide rapidly and are therefore strongly affected by these drugs. Antiseptic and analgesic mouthwashes may be prescribed to numb the discomfort. Surgery, radiation therapy, chemotherapy and/or malnutrition are all a strain on the body and often cause fatigue. more...



Pancreatic Cancer Troubling Signs and

The fear of pain is the leading concern of most patients with advanced pancreatic cancer. Often a vague mid-abdominal pain is one of the first symptoms of pancreatic cancer. Inadequately treated pain can have profound negative effects on the psychosocial and even physical well-being of pancreatic cancer patients, and may subject patients to unnecessary anxiety and even depression. Nausea and vomiting may be a problem in up to 40% of pancreatic cancer patients. The causes can range from the more mundane to the serious – and may, for example, include laxative overuse, malabsorption, anxiety or stress, infection, medication side-effect, radiation therapy, the effect of the cancer itself, surgery, pancreatic enzyme deficiency — and can even represent a sign of bowel obstruction. The treatment is individual, but should include evaluating and correcting any underlying problems. Weight loss and muscle wasting (cachexia) are common and occur in over 90% of patients with pancreatic cancer. Some patients are unable to tolerate a diet which is high in fat and protein, and in others the onset of diabetes may occur. These factors may have significant consequences on patients and their caregivers as, in the midst of these matters, a diet which is both palatable and effective is implemented. But progress has been made and options continue to improve, to the benefit of affected pancreatic cancer patients. In some pancreatic cancer patients, there can be a troubling large collection of fluid in the abdominal cavity itself, which increases abdominal girth. Typically described as a loss of customary energy levels and even as effecting mental processes, the fatigue of pancreatic cancer can be debilitating. The range of causes of fatigue under these circumstances is very large and can include such factors as the pancreatic cancer itself, sleeplessness (possibly due to pain or for other reasons), anemia, chemotherapy side-effect, anxiety or depression, medication side-effect (including pain medication), infection, electrolyte disturbance, or dehydration. more...



Cancer and Weight Loss as a Symptom

Unexplained weight loss can be a symptom of many conditions - cancer included. Weight Loss and Cancer. Unintentional weight loss can be a symptom of cancer , though vague and non-specific. When To See Your Doctor About Weight Loss. Generally, you should see your doctor if you have lost 5 percent of your body weight within six months or less and have done so without modifying your diet or exercising. Your doctor may ask you several questions to help identify why you are losing weight. Your doctor will want to know the basics like when you first started to lose weight and how much you have lost. Remember, Weight Loss Doesn't Mean You Have Cancer. You may also get a better understanding of what your symptoms, like weight loss , may mean by using the About.com Symptom Checker , an interactive health education tool. more...



Pancreatic cancer - Symptoms - NHS Choices

Pancreatic cancer - Symptoms  Symptoms of pancreatic cancer  The pancreas is actually two glands in one, and symptoms depend on which part is affected. The exocrine pancreas produces digestive enzymes, which break down food so they can be absorbed by your body. Most cases of pancreatic cancer are in the exocrine pancreas, and the three most common symptoms are: It's important to remember that these symptoms can be caused by many different health conditions and aren't usually the result of cancer. Pancreatic cancer is more likely to cause weight loss than some other cancers because the pancreas produces digestive enzymes, which help food to be absorbed into your body. Without it, the body can't move glucose (sugar) out of the blood and into your cells. The main symptoms of diabetes include: You may develop diabetes  if you have pancreatic cancer, because it can produce chemicals that interfere with the normal effect of insulin. Other possible symptoms of pancreatic cancer include: more...



Pancreatic cancer symptoms

Pancreatic cancer symptoms. Pancreatic cancer symptoms: Location matters. By the time it's large enough to cause symptoms, pancreatic cancer has generally grown outside the pancreas . Pancreatic cancer in the head of the pancreas tends to cause symptoms such as weight loss , jaundice (yellow skin ), and fat in the stool, with or without abdominal pain . Pancreatic cancer in the body or tail of the pancreas usually causes stomach pain and weight loss. more...



Pancreatic Cancer and Weight Loss - Page 3

Pancreatic Cancer and Weight Loss. Pancreatic cancer refers to a malignant neoplasm of the pancreas. The most common type of pancreatic cancer, accounting for 95% of th. 65,557 conversations around the web about Pancreatic Cancer to help you make a decision. Treato found 1,818 discussions about Weight Loss and Pancreatic Cancer on the web. 2.77% of the posts that mention Pancreatic Cancer also mention Weight Loss (1,818 posts) Pancreatic Cancer. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. Treato does not provide medical advice, diagnoses or treatment. more...



Interview with Dr. Kimberly Kirkwood

Kimberly Kirkwood, a pancreatic and gastrointestinal surgeon, who discusses the warning signs of pancreatic cancer , technological advances for early diagnosis, and surgical treatments and follow-up care that are saving lives. Pancreatic cancer can be a terrifying diagnosis, and often it's preceded by just vague symptoms, but there are advances being made in diagnosis and in surgical approaches that can really make a difference. This is where we connect you with a leading UCSF medical expert talking about significant health conditions, and one of the scariest diagnoses is pancreatic cancer. What are some of the symptoms that may be vague early on for pancreatic cancer? Kirkwood, let's say that something is seen in and around the pancreas that's nonmalignant. What's the correlation between these nonmalignant masses and something that could be cancer later on? We're going to talk about surgical approaches in just a minute, but the truth is maybe the mortality from pancreatic cancer is so great because it's discovered later and for whatever reason, many people are not offered surgery. Is there any new data about what's going on there or how often that's the case, and then we'll talk about what you can do that makes a difference at UCSF. We now know that the majority of patients in the country who have localized tumors, that is tumors that are within the pancreas and have not spread, are actually not being seen by surgeons who have the expertise to remove them. We partner with the local oncologists so that the patient may come for their surgery at UCSF but can still receive their oncology care locally, and I think that we're trying very hard now to break down some of these barriers to access to UCSF. I think this has really advanced the quality of life for patients with benign or premalignant tumors and may be appropriate for some cancers. Absolutely, and sometimes all we do is reinforce the original treating surgeon's or treating oncologist's opinion, but we often provide that depth of expertise and that breadth of expertise that helps them to understand where they are in the whole scheme of pancreatic cancer patients and what's down the road. We've learned a lot from the advances in breast cancer and colon cancer therapy in the last decade, and I think this will be the decade in which we apply that knowledge to pancreatic cancer. Kimberly Kirkwood is a pancreatic cancer surgical specialist and gastrointestinal surgeon, and she is the Surgical Director at the Pancreas Cancer Center at UCSF. more...



Pancreatic Cancer Symptoms, Causes

Frequent sites of metastasis for pancreatic cancer include the liver, the lymph nodes , and the lining of the abdomen (called the peritoneum). In general, the signs and symptoms of pancreatic cancer can be produced by exocrine or endocrine cancer cells. Exocrine pancreatic cancer signs and symptoms can include. The signs and symptoms of endocrine pancreatic cancers are often related to the excess hormones that they produce and consequently to a variety of different symptoms. Such symptoms are related to the hormones and are as follows: How is the diagnosis of pancreatic cancer made? A pancreatic mass and the suspicion of pancreatic cancer is then raised and a biopsy is performed to yield a diagnosis. The tumor marker most commonly associated with pancreatic cancer is called the CA 19-9. It is often released into the bloodstream by pancreatic cancer cells and may be elevated in patients newly found to have pancreatic cancer. Unfortunately, the CA 19-9 test is not specific for pancreatic cancer. more...



Pancreatic Cancer Signs and Symptoms

Read the Understanding Pancreatic Cancer - Diagnosis and Treatment article > > Pancreatic Cancer Symptoms: Location Matters. By the time it's large enough to cause symptoms, pancreatic cancer has generally grown outside the pancreas . Pancreatic cancer in the body or tail of the pancreas usually causes belly and/or back pain and weight loss. Pancreatic Cancer and Gastrointestinal Symptoms. Pancreatic Cancer: Whole-Body Symptoms. As it grows and spreads, pancreatic cancer affects the whole body. more...



Signs and Symptoms of Cancer

Signs and Symptoms of Cancer. How does cancer cause signs and symptoms? The signs and symptoms will depend on where the cancer is, how big it is, and how much it affects the organs or tissues. If a cancer has spread (metastasized), signs or symptoms may appear in different parts of the body. This pressure causes some of the signs and symptoms of cancer. Cancer can also cause the immune system to react in ways that produce these signs and symptoms. If cancer is not the cause, a doctor can help figure out what the cause is and treat it, if needed. What are some general signs and symptoms of cancer? You should know some of the general signs and symptoms of cancer. Along with the general symptoms, you should watch for certain other common signs and symptoms that could suggest cancer. Sores on the penis or vagina may either be signs of infection or an early cancer, and should be seen by a health professional. The signs and symptoms listed above are the more common ones seen with cancer, but there are many others that are not listed here. more...



Why does cancer cause weight loss

It was always thought that cachexia was the result of cancer spreading and consuming the body, with loss of appetite and nutritional complications causing the body to waste away. But the researchers found that Fn14, a receptor on a cell’s membrane which is often present on cancer cells, can cause cachexia. “It’s normally switched on to do its job, and then it’s switched off when the job is finished. What this means is that the tumour cells send signals to the rest of the body, and it’s these signals that are responsible for causing the muscle wasting and the other symptoms of cachexia.” While Dr Johnston said Fn14 has “been known to be involved in cancer”, she said it was a surprise to find out that it was also the cause of cachexia. more...



Loss of appetite - Canadian Cancer Society

Severe loss of appetite can cause weight loss and malnutrition. Try eating small meals and snacks throughout the day. Appetite is very much affected by how food looks and by the eating environment. Try to help make meals appealing and fun. You can try experimenting with different foods to help cover up tastes and smells that bother you and make food appealing again. Spices make the mouth water and change the taste of food. You can help prevent weight loss by increasing the nutritional value of the food you eat, especially with calories and protein. Eat foods high in calories and protein when the appetite is poor. You can try the following to help stimulate your appetite. Eating with someone else distracts attention from food and can increase the amount eaten. Feeding tubes may be appropriate if your loss of appetite is temporary and not caused by advanced cancer. Talk to your healthcare team about how you can help manage your child’s loss of appetite and make sure they are getting proper nutrition. Try to serve foods and drinks that the child asks for or that are easy to eat or drink. more...



Signs and symptoms - Pancreatic Cancer UK

Signs and symptoms of pancreatic cancer. Pancreatic cancer doesn't usually give rise to any symptoms or signs in the early stages. As the cancer grows the symptoms it causes will depend on the  type of pancreatic cancer  and where it is in the pancreas. It is important to remember that any of the symptoms described here are common for lots of illnesses and may not be a sign of pancreatic cancer. Most common symptoms of pancreatic cancer. Their symptoms can be very vague and depend on whether the tumour is in the head, body or tail of the pancreas. Cancer growing in the pancreas can block the bile duct so that bile and bilirubin keep building up in the body. Pancreatic cancer can affect the ability of the pancreas to produce digestive enzymes that help to digest food, especially high fat food. Other common symptoms of pancreatic cancer. If the pancreas is inflamed or the ducts are blocked because of the tumour, this can cause a high temperature and shivering. The list of symptoms above for the  most common symptoms of pancreatic cancer  are also applicable to non functioning neuroendocrine tumours. Symptoms include watery diarrhoea, high blood pressure and flushing of the face. more...



Pancreatic cancer - Mayo Clinic

Pancreatic cancer. Pancreatic cancer begins in the tissues of your pancreas — an organ in your abdomen that lies horizontally behind the lower part of your stomach. Pancreatic cancer often has a poor prognosis, even when diagnosed early. Signs and symptoms may not appear until pancreatic cancer is quite advanced and complete surgical removal isn't possible. What you need to know about cancer of the pancreas. National Cancer Institute. Pancreatic adenocarcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. Psychological distress in patients with pancreatic cancer — An understudied group. Pancreatic SPOREs. Distinguishing pancreatic cancer from autoimmune pancreatitis. American Cancer Society. more...



Cachexia in pancreatic cancer : new treatment

Cachexia has long been recognized as a direct cause of reduced quality of life complicating both the early and late stages of cancer, particularly in patients with tumours originating in the pancreas, oesophagus, stomach or lung. Taken together, these changes are thought to contribute to the reduced quality and quantity of life associated with cachexia. Patients with pancreatic cancer have the highest prevalence and often develop the most severe degrees of cachexia. The ageing process is often paralleled by decreases in muscle and increases in fat mass, which may culminate in sarcopenic obesity. The present study by Aslani and co-workers 2 examines the relationship between tumour stage and altered body composition in patients with resectable pancreatic cancer. In the study by Aslani et al., 2 patients with more advanced disease (involved surgical margins) are shown to have more significant alterations in body composition, notably decreased body protein mass and fat mass. It remains to be seen whether these early changes predict the later degree and impact of cachexia on outcome. Interestingly, the presence of muscle wasting in obese patients with advanced pancreatic cancer is associated with shortened survival. Such issues might be resolved by the development of effective therapy for cachexia and concomitant use of activity monitoring in proof-of-concept trials. Therapies based on these pathways are currently in Phase I and Phase II clinical trials in cancer patients, and the demonstration of their potential efficacy to stem losses of weight and muscle, alter physical function and improve quality of life will be available in the foreseeable future. 2 However, for the majority of patients with pancreatic cancer, resection is not possible and palliation with systemic chemotherapy is the main method of prolonging, albeit limited, survival. Cachexia is associated with lower tolerance for chemotherapy, which limits the total dose that can be delivered, the number of symptomatic responses and any survival advantage that might be accrued. more...



Pancreatic Cancer and Weight Loss

Pancreatic Cancer and Weight Loss. Pancreatic cancer refers to a malignant neoplasm of the pancreas. The most common type of pancreatic cancer, accounting for 95% of th. 65,555 conversations around the web about Pancreatic Cancer to help you make a decision. Treato found 1,818 discussions about Weight Loss and Pancreatic Cancer on the web. 2.77% of the posts that mention Pancreatic Cancer also mention Weight Loss (1,818 posts) Pancreatic Cancer. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. Treato does not provide medical advice, diagnoses or treatment. more...



Signs and symptoms of pancreatic cancer

The symptoms of exocrine pancreatic cancers and pancreatic neuroendocrine tumors (NETs) are often different, so they are described separately. Still, if you have any of these symptoms, it’s important to have them checked by a doctor so that the cause can be found and treated, if needed. These cancers can press on the duct and cause jaundice while they are still fairly small, which can sometimes lead to these tumors being found at an early stage. Pancreatic cancer is not the most common cause of jaundice. Pancreatic cancer can also sometimes enlarge the liver, especially if the cancer has spread to the liver. Symptoms can include pain, swelling, redness, and warmth in the affected leg. Most of the symptoms that can be caused by a glucagonoma are mild and are more often caused by something else. Often, they are not found until they spread to the liver, when they cause problems like jaundice and pain. The liver breaks these substances down before they can reach the rest of the body and cause problems. Because of this, carcinoid tumors often don’t cause symptoms until they spread outside the pancreas. When these tumors do spread, it is most often to the liver. Most of these are cancers and start to cause problems as they get larger or spread outside the pancreas. Symptoms can be like those from exocrine pancreas cancers, including jaundice (yellowing of the eyes and skin), belly pain, and weight loss. This can enlarge the liver, which can cause pain and loss of appetite. more...



Symptoms of Pancreatic Cancer

Many symptoms of pancreatic cancer are mild at first, so patients may often be unaware of the potential seriousness of them. However, when the bile duct becomes blocked - for any reason - jaundice can occur. In Pancreatic Cancer: Jaundice typically occurs in pancreatic cancer when a tumor in the head of the pancreas first narrows, then obstructs the common bile duct, blocking the flow of bile. In Pancreatic Cancer: Digestive difficulties including indigestion, nausea, weight loss, a poor appetite, and diarrhea, can arise as a result of pressure from a pancreatic cyst or tumor on the stomach or the small intestine that causes a block in the digestive tract. If a tumor blocks the pancreatic duct, insufficient pancreatic juices in the intestines can lead to poor absorption and diarrhea, as the undigested food passes quickly through the digestive tract. Other Causes: Stomach pain, nausea, vomiting, and diarrhea can be caused by a number of conditions. However, there are no distinguishing characteristics associated with pancreatic cancer when the weight loss is due to malignant cancer cells monopolizing the body's nutrients. Other Causes: Unexplained weight loss can also be caused by some infections or parasites in the digestive tract. If the cancer spreads to the peritoneum, it can cause irritation and cause fluid to build up. Other Causes: Pancreatic ascites can also occur if a cyst or a pseudocyst in the pancreas bursts, allowing the pancreatic juices to seep into the abdominal cavity. However, cirrhosis of the liver, and specifically alcoholic cirrhosis, is the most common cause for ascites. In Pancreatic Cancer: Sudden onset of diabetes in people with normal body mass index is often a warning sign of pancreatic abnormalities and can be a symptom of pancreatic cancer. more...



Pancreatic Cancer : Types, Treatment, Causes

Nugent is a medical oncologist specializing in gastrointestinal cancers with a special interest in pancreatic cancer. Stuart is a medical oncologist specializing in the study and treatment of cancers involving the gastrointestinal tract, with a special interest in tumors involving the liver. The pancreas, located in the abdomen, has endocrine and exocrine functions; cancer cells can develop from both types of functional cells. Pancreatic cancer is highly lethal because it grows and spreads rapidly and often is diagnosed in its late stages. Pancreatic cancer is difficult to diagnose, and the diagnosis is often made late in the course of the disease. Symptoms and signs of pancreatic cancer in its late stage include weight loss and back pain . The only curative treatment is surgical removal of all cancer and a pancreatic transplant; however, most patients are not eligible for a pancreas transplant. Chemotherapy for metastatic pancreatic cancer can extend life and improve the quality of life. Many organizations exist to help provide information and support for patients and families fighting pancreatic cancer. Cancer that starts in the pancreas is called pancreatic cancer. more...



Pancreatic cancer symptoms

The most common types of cancer of the pancreas are exocrine tumours. The symptoms can be quite vague. And the symptoms can also vary depending on where the cancer is in your pancreas – in the head, body or tail. Some of the most common symptoms include pain in the stomach area or back, jaundice and weight loss. Symptoms of jaundice can include yellowing of the skin and whites of the eyes, severe itching, darkened urine, and pale coloured stools (bowel motions). Pain is more common in cancers of the body and tail of the pancreas. It can begin in the stomach area and spread around to the back. The pain is worse when you lie down and is better if you sit forward. Jaundice is yellowing of the skin and whites of the eyes. Jaundice is more common with cancer of the head of the pancreas because the tumour blocks the bile duct . There are other symptoms that you can have with cancer of the pancreas. You may have any of these symptoms from before you are diagnosed. It is a common problem in the general population, and for most people it isn't a sign of cancer. Pain, redness and swelling around the area where the clot is. As these tumours get larger or spread they might cause symptoms such as pain, a lump in the abdomen or jaundice . more...



Chronic Pancreatitis - UCLA Pancreas Center

Clinical Manifestations: In 95% of patients with chronic pancreatitis, the principal symptom is abdominal pain. Radiologic Features: In 30 to 50% of patients with chronic pancreatitis, plain x-rays of the abdomen reveal pancreatic calcifications. Indeed, when calcifications are present, the diagnosis of chronic pancreatitis is certain even if there is no clinical evidence of pancreatic disease. Most patients are chronic alcoholics with recurring episodes of abdominal pain, diabetes, weight loss, pancreatic calcifications and some evidence of malabsorption. Occasionally the distinction between chronic pancreatitis and pancreatic cancer may be difficult. This may occur when there is no previous history of pancreatitis, when the patient presents with jaundice and pain is not a prominent part of the picture, and when weight loss is significant. The medical management of pain in patients with chronic pancreatitis should include the cessation of all alcohol intake and cessation of smoking, if the patient is a smoker. Sphincterotomy or sphincteroplasty of the sphincter of Oddi has no place in the treatment of pain in patients with this disease. In patients with alcoholic chronic pancreatitis, it is of interest to review mortality statistics unrelated to surgical intervention for complications of the disease. Recent studies reveal a 2-5 times increase in the incidence of pancreatic cancer in patients with chronic pancreatitis from a variety of causes. more...



Types of diet problems - Cancer Research UK

The type of cancer you have. Your type of cancer can affect how likely it is that you will have digestive problems. As many as 1 in 4 people diagnosed with cancer have loss of appetite. This is weight loss when you are not trying to. Losing weight is often associated with loss of appetite. Your body may not be absorbing all the fat, protein and carbohydrate from the food you eat. How much weight you lose can depend on the type of cancer you have. About 6 out of 10 people (60%) with lung cancer and 8 out of 10 people (80%) with stomach cancer, pancreatic cancer or oesophageal cancer have lost a significant amount of weight by the time they are diagnosed. If you are not dieting and you lose more than 5% of your normal weight in 1 month, or 10% in 6 months, your doctor will want to find out the cause. Anorexia just means loss of appetite and is often associated with cachexia, but not always. Cachexia in advanced cancer can be very upsetting and make you feel very weak. Because your body is using up energy faster than it is getting it, you can have severe weight loss even if you are eating normally. This can all be made worse because of the side effects of cancer treatment you are having. more...



Rapid Weight Loss and Cancer

Rapid Weight Loss & Cancer. Rapid weight loss may be a sign of cancer. One of the first signs of cancer is rapid weight loss. Cancer cells rob your body of nutrients, causing weight loss, poor nutrition and a general decline in health. Depending on the type of cancer, the warning signs may vary. Causes of Rapid Weight Loss. Your doctor can evaluate your weight loss and find the cause and recommend the proper treatment. more...



Pancreatic Cancer Facts - Pancreatic Cancer

Pancreatic Cancer Facts. Home > Pancreatic Cancer > Pancreatic Cancer Facts. An estimated 53,070 Americans will be diagnosed with pancreatic cancer in the U. Pancreatic cancer is the 3rd leading cause of cancer-related death in the United States. Pancreatic cancer has the highest mortality rate of all major cancers. Surgical removal of the tumor is possible in less than 20% of patients diagnosed with pancreatic cancer. more...



Pancreatic Cancer Symptoms - Cancer advice

Pancreatic Cancer Symptoms. Signs and Symptoms of Pancreatic Cancer. Jaundice , a painless condition marked by the yellowing of the skin and eyes, commonly occurs in people pancreatic cancer. It is one of the first symptoms of pancreatic cancer a person usually notices, along with abdominal pain. Appetite loss is a symptom of hundreds of diseases and conditions, including pancreatic cancer. In some cases, pancreatic cancer may impede the pancreas' ability to produce insulin, resulting in diabetes . What to Do If You Have Pancreatic Cancer Symptoms. If you are experiencing any of the symptoms of pancreatic cancer, see your doctor. Even if they are not related to pancreatic cancer, in the end, they do warrant a medical evaluation. Is Pancreatic Cancer Screening Available? more...



Pancreas, Sweating and Weight Loss

| By Emma Cale. Symptoms such as sweating and weight loss can accompany a number of diseases and conditions that affect the pancreas, including acute pancreatitis, chronic pancreatitis, pancreatic abscess and pancreatic cancer. Treatment for acute pancreatitis involves a hospital stay during which foods and fluids are given intravenously to allow the pancreas time to heal. Chronic Pancreatitis. In chronic pancreatitis, the organ often shuts down, which effectively shuts down digestion, so the body simply excretes all or most of the food you ingest. Treatment for chronic pancreatitis also involves a hospital stay – typically of longer duration – until the pancreas begins to function normally. more...



Unexplained Weight Loss - Pancreatic Cancer Action Network

Weight loss is a common problem in patients with pancreatic cancer. The weight loss can be associated with treatment or the cancer itself. Unexplained weight loss may be an early symptom of pancreatic cancer and can occur without any pain or apparent change in digestion. In addition, please note that any personal information you provide to Pan CAN’s associates during telephone and/or email communications may be stored and used to help Pan CAN achieve its mission of assisting patients with, and finding cures and treatments for, pancreatic cancer. Information also may be provided in aggregate or limited formats to third parties to guide future pancreatic cancer research and treatment efforts. more...



Pancreatic cancer : MedlinePlus Medical

If tests confirm you have pancreatic cancer, more tests will be done to see how far the cancer has spread within and outside the pancreas. Surgery may be done if the tumor has not spread or has spread very little. When the tumor has not spread out of the pancreas but cannot be surgically removed, chemotherapy and radiation therapy together may be recommended. With advanced cancer, the goal of treatment is to manage pain and other symptoms. This can help relieve loss of appetite, jaundice, and itching of the skin. You can ease the stress of illness by joining a cancer support group . But in most people, the tumor has spread and cannot be completely removed at the time of diagnosis. Chemotherapy and radiation are often given after surgery to increase the cure rate (this is called adjuvant therapy). For pancreatic cancer that cannot be removed completely with surgery or cancer that has spread beyond the pancreas, a cure is not possible. Pancreatic cancer, cystic pancreatic neoplasms, and other nonendocrine pancreatic tumors. more...



Mechanisms of Cancer Cachexia - Home

Weight loss in cancer patients is due to depletion of both adipose tissue and skeletal muscle mass, while the nonmuscle protein compartment is relatively preserved, thus distinguishing cachexia from simple starvation ( 77 ). Also in patients with pancreatic cancer, although nutritional supplementation is unable to reverse the loss of body weight, there is a relationship between calorie intake and survival ( 196 ). LMF has also been shown to increase the sensitivity of WAT to the lipolytic effects of catecholamines, as happens in adipocytes from patients with cancer cachexia ( 5 ), through an increased expression of Gαs and a decreased expression of Gαi ( 114 ). Glucocorticoids may be responsible for the increased ZAG expression seen in mice with cachexia, since the glucocorticoid receptor agonist RU 38486 attenuated both the loss of body weight and ZAG expression in WAT ( 225 ). However, another study has questioned the role of PIF in weight loss in patients with metastatic gastric/esophageal and lung cancer ( 119 , 276 ). The effect on skeletal muscle was due to a depression in protein synthesis (by 50%) and an increase in protein degradation (by 50%) ( 157 ). PIF produced a specific increase in m RNA levels for ubiquitin, E 214k, and the C 9 proteasome subunit in gastrocnemius muscle, but not heart ( 156 ), suggesting that protein degradation was mediated through an increased expression of the ubiquitin-proteasome pathway. Resveratrol was found to significantly attenuate weight loss and protein degradation in muscle through the ubiquitin-proteasome pathway ( 289 ). 8 ), and this has been shown to be responsible for the depression of protein synthesis and increase in protein degradation through the ubiquitin-proteasome pathway ( 66 ). However, body composition analysis of patients who gained weight showed that the weight gain was due to an increase in fat and not lean body mass ( 155 ). A secondary analysis showed that increased plasma levels in the experimental group were associated with an increase in weight and lean body mass. The majority of patients with gastrointestinal cancer have an APR, which has been suggested to contribute to weight loss, and therefore, if this is downregulated, weight loss should also be attenuated. more...



Pancreatic cancer - Evidence - Based Clinical

Two types of cancer can affect the pancreas: ●The most common is cancer of the exocrine pancreas that originates in the pancreatic ducts ( figure 1 ). Most people with pancreatic cancer have pain and weight loss, with or without jaundice (yellowing of the skin): The block is caused by the cancer. Once pancreatic cancer is diagnosed, the next step is to determine its stage. ●The size of the cancer. However, surgery is often not possible; pancreatic cancer is often advanced by the time it is diagnosed. If surgery is not possible, radiation therapy, chemotherapy, or both are often used to shrink the cancer, reduce symptoms, and prolong life. The best treatment for locally advanced pancreatic cancer is not clear, but surgery is not usually offered initially. Treatment of stage IV (metastatic) disease — For patients who are initially diagnosed with metastatic pancreatic cancer (stage IV), chemotherapy might be recommended to slow the spread of the cancer and relieve symptoms. (See "Chemotherapy for advanced exocrine pancreatic cancer" .) In many people with pancreatic cancer, the disease cannot be cured. Ending cancer treatment does not mean ending care for the patient. more...



Pancreatic Cancer : Causes, Symptoms and

Pancreatic Cancer: Causes, Symptoms and Treatments. Cancer is a class of diseases characterized by out-of-control cell growth, and pancreatic cancer occurs when this uncontrolled cell growth begins in the pancreas. Tumors then interfere with the main functions of the pancreas. In the United States each year, over 30,000 people are diagnosed with pancreatic cancer. What is the pancreas? The pancreas contains exocrine and endocrine glands that create pancreatic juices, hormones, and insulin. Over 95% of the pancreas is made up of exocrine glands and ducts. What Does The Pancreas Do? Pancreatic cancer is categorized depending on whether it affects the exocrine or endocrine functions of the pancreas. A CT scan of the pancreas. Tumors that affect the exocrine functions are the most common type of pancreatic cancer. Tumors that affect the endocrine functions of the pancreas are called neuroendocrine or islet cell tumors, but these are fairly uncommon. On the next page we look at the causes and symptoms of pancreatic cancer. On the final page we discuss how pancreatic cancer is diagnosed and the available treatments for pancreatic cancer. more...




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